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KMID : 0616120190500010046
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Korean Journal of Pharmacognosy
2019 Volume.50 No. 1 p.46 ~ p.52
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Anti-obesity Effect of Vegetable Formula on Obese Mice in High Fat Diet
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Lee Jae-Hyeok
Shin Tae-Yong
Park Jeong-Sook
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Abstract
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This study was conducted to investigate the cholesterol and Triglyceride (TG) lowering and anti-obesity effects of water extract of vegetable formula (onion 25%, carrot 20%, Cabbage 20%, Sweet Pumpkins 20%, Chinese plum 5%, turmeric 5%, morus leaves 5%, SLS) in mice fed high fat-diet. ICR mice were divided into 3 groups; a normal diet group (ND), a high-fat diet group (HFD), a high-fat diet and SLS with 300 mg/kg treated group (HFD+SLS). Body fat gain was increased by high-fat diet and HFD+SLS group showed a definite weight loss. The total cholesterol level in the HFD+SLS group was 328.4 mg/dl which was 27.4% lower than that in the HFD group and the cholesterol-lowering effect of SLS was confirmed. The HFD + SLS group showed 118.1 mg/dl and the triglyceride level in the serum was decreased by 88.7% compared to the HFD group and SLS significantly decreased blood triglyceride levels. RT-PCR showed that the expression of PPAR-γ and the target gene SCD-1 was inhibited in a dose-dependent manner in the SLS-treated group. These results suggest that the SLS water extract may have a cholesterol and triglyceride-lowering effect and inhibit the expression of PPAR-γ and SCD-1 to have an anti-obesity effect.
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KEYWORD
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Obesity, Vegetable formula, PPAR-γ, SCD-1, Cholesterol, Triglyceride
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